By Libby Roerig, Indiana State University
Nearly 30 years of fieldwork coupled with cutting-edge technology has yielded important genetics insight recently published by the academic journal Current Biology and reviewed in Science Magazine.
For Elaina Tuttle, it’s like winning an Oscar.
“I think of all the researchers throughout the years, all the field assistants and graduate assistants who have been collaborators. It’s nice because even though they may not be in authorship, a little part of them is in there,” said Tuttle, professor of biology and associate dean of graduate programs at Indiana State University.
“I think about my first years, not knowing what we’re doing, and now I think about the well-oiled machine we are with the white-throated sparrow project.”
Tuttle and fellow State biology Professor Rusty Gonser have led 27 years’ research into white-throated sparrows at Cranberry Lake in New York. Their efforts have led to greater understanding of the birds’ supergene, its apparent degradation and the species’ evolution.
The white-throated sparrow has two morphs — tan and white — that differ in color and behavior because of a chromosomal inversion.
“There’s this large chunk of chromosome two that is rotated. It acts like a supergene and prevents any sort of recombination. It links those genes so there are no changes in them, generation after generation after generation,” Tuttle said.
With these supergenes, the good traits are passed on together to offspring and never unlinked.
“If you’re really aggressive and it’s good to be aggressive with your bright color, that’s always linked together and passed on together,” she said. “It prevents the breakup of good combinations. But it can also harbor bad combinations.”
By sequencing the genome, Tuttle and the team of researchers — including Sycamore graduate students Marisa Korody and Adam Betuel — have identified more than 1,000 genes and where they are located.
“What we find is that in the white morph, (the supergene is) degrading,” she said. “Not only is the white supergene degrading, but it’s dragging the tan supergene along with it. It’s called purifying selection — it’s getting rid of all those bad combinations. You’re going to be left with only the good combinations.”
The findings have important parallels to human sex genes.
“So, kind of like the X and the Y sex chromosomes in humans, the X chromosome is really large, and the Y chromosome is really tiny. They think it was (once equal),” she said.
They also unlocked key components to the birds’ evolution — the white morph is newer, and the tan morph is the ancestral form.
“By using these evolutionary analysis tools, we were able to figure out there was probably hybridization with some extant or extinct species a long time ago,” she said.
The morphs breed with the opposite — a tan male with a white female and so on — which perpetuates the species and its health.
“We were able to show that when white pairs with white, there’s detriment,” Tuttle said. “They have genetic problems. They also have increased promiscuity — they’re not so happy together. It does pay to pair with the opposite morph.”
Typically, researchers have genomics data or they have field data. “You don’t often have both integrated into a nice story together,” she said.
And that field data dates back nearly three decades.
“We can go back in history and do the genomics from samples from 1988 and see how genes change over time. It’s a really rich database,” she said.
Until genome sequencing capabilities caught up with Tuttle, she says it was like having a black box that needed to be unlocked.
“I knew there were secrets in there, and we’re just beginning to see,” she said. “Now, the data can be mined by us and other researchers because it’s on a public database.”
As questions are answered, even more are asked.
“I’m excited. There’s so many other things we can find out — how genes arise, how they’re maintained, how they work,” she said. “We’re even thinking about doing epigenetics, which is how genes are turned on or off. One of the future projects we’re looking at is how stress turns on certain genes. That’s a big thing in human disease, as well. Stress turns on certain genes that cause disease later in life. It’s a good model for human behavior as well.”
Countless Indiana State undergraduates and post-doctoral students, as well as students from other universities — domestic and international — have participated in Tuttle’s research. And this latest paper will become the basis of limitless future work.
“It made it even more rewarding having to go through the struggle of waiting for the technology to get there,” she said. “This is probably my pinnacle paper. Finding the behavioral polymorphism was the beginning of my career with the sparrows. I’m going to still have papers, but this is a big turning point.”
To watch a video about Tuttle’s research, go to http://www.cell.com/current-biology/abstract/S0960-9822%2815%2901562-6.
Office of Gov. Mike Pence
INDIANAPOLIS – Governor Mike Pence and Commissioner for Higher Education Teresa Lubbers joined Indiana business and local government leaders today to kick off “You Can. Go Back.”— a coordinated campaign to help 750,000 Hoosier adults who have some college credit but no degree finish what they started. The statewide effort is a key strategy in reaching Indiana’s goal to increase the percentage of Hoosiers with education beyond high school to 60 percent by 2025.
“There are 750,000 Hoosier adults who started working toward a degree or credential that will help them in their professional lives but for one reason or another, they had to put their education on hold,” said Governor Pence. “What we are doing here today is telling these Hoosiers, ‘We can help. And yes, you can go back.’ We want to improve the quality of our workforce, and help put Hoosiers on a path to even greater success. To achieve this goal, it is imperative that we look beyond our K-12 pipeline. Our ‘You Can. Go Back.’ campaign will encourage a continuing education that helps working Hoosiers meet the qualifications of the fastest growing, high-wage jobs that will provide opportunity and improve lives.”
With support from state lawmakers and Indiana colleges, the Commission for Higher Education (CHE) is reaching out directly to prospective returning adults and easing their transition back to college with a variety of special programs and incentives, including $1,000 scholarships through a $7.5 million state grant, flexible class schedules and online courses, college credit for work and military experience, grade- and debt-forgiveness programs, and tuition discounts.
“Many adults who started a degree or credential but didn’t finish have a strong desire to return to college, but they don’t know where to start,” CHE Commissioner Lubbers said. “You Can. Go Back. will guide students through the process of returning to school and give them the support they need to be successful.”
This month, thousands of former college students will receive messages in their mailboxes and email inboxes highlighting the benefits of completing their degree and directing them to resources designed to support their return to school. At YouCanGoBack.org, Hoosiers will be matched to college programs based on their interests and career goals before being connected to dedicated “You Can. Go Back.” campus ambassadors at well-matched colleges.
Indiana state leaders have called upon businesses and local communities as essential partners in the “You Can. Go Back.” campaign. Columbus Mayor Jim Lienhoop took part in today’s official campaign launch, highlighting the importance of postsecondary education to the economic vitality of cities and towns.
“Approximately 20 percent of adults—about 35,000 people ages 25-64 in our southeast Indiana workforce region—have some college but no degree. Employers in our community are in desperate need of highly skilled people to fill jobs, especially in the advanced manufacturing and health care sectors, which makes up nearly 50 percent of our workforce,” Lienhoop said. “The City of Columbus strongly supports “You Can. Go Back.” because of its potential to help meet this workforce need.”
As part of the “You Can. Go Back.” roll-out, CHE gathered input from Indiana businesses on what types of education benefits they currently offer employees and what challenges they face in providing or expanding those benefits. Comcast was the partnering business for the “You Can. Go Back.” announcement. The company already offers employees $5,750 in annual tuition reimbursement support, but Comcast is also working to expand education benefits.
“The state is stepping up to make sure this opportunity exists for Hoosiers, but it is incumbent upon the businesses in Indiana to make sure that we provide a path that leads directly to a better educated workforce,” said Mike Wilson, Comcast Indiana Public Relations Director.
As one of the largest employers in our state, Governor Pence has directed the State Personnel Department to share information about “You Can. Go Back.” with state employees. State agencies such as the Department of Workforce Development and the Family and Social Services Administration are helping publicize the effort across the state in local WorkOne and Division of Family Resources offices.
Learn more about “You Can. Go Back.” at YouCanGoBack.org and related resources for returning adults atLearnMoreIndiana.org/adult-learners.